Seropositive rheumatoid arthritis

RHEUMA_SEROPOS

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Seropositive rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 8479 5815 2664
Unadjusted prevalence (%) 2.38 2.93 1.69
Mean age at first event (years) 54.42 52.56 58.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.56 [2.02, 3.24] 5.8e-15 1147
15 years 0.01 1.75 [1.47, 2.08] 4.1e-10 558
5 years 0.00 2.42 [2.06, 2.84] 5.5e-27 253
1 year 0.00 3.51 [2.69, 4.57] 1.8e-20 69

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS – Seropositive rheumatoid arthritis
GWS hits: 22

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis
after Seropositive rheumatoid arthritis

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis

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