Type 1 diabetes, wide definition

T1D_WIDE

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

8233

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T1D_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Type 1 diabetes, wide definition based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 8233 3961 4272
Unadjusted prevalence (%) 2.31 2.00 2.71
Mean age at first event (years) 28.04 25.95 29.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.62 [1.87, 3.67] 1.9e-8 1070
15 years 0.01 1.98 [1.53, 2.57] 1.8e-7 494
5 years 0.00 2.19 [1.70, 2.83] 1.2e-9 138
1 year 0.00 2.52 [1.66, 3.82] 1.5e-5 28

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T1D_WIDE – Type 1 diabetes, wide definition
GWS hits: 47

Survival analyses between endpoints

Plot

before Type 1 diabetes, wide definition
after Type 1 diabetes, wide definition

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Drugs most likely to be purchased after Type 1 diabetes, wide definition