Type 1 diabetes, strict definition

T1D_STRICT

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not E4_DM2

299608

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

3312

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T1D_STRICT

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 3312 1665 1647
Unadjusted prevalence (%) 0.93 0.84 1.05
Mean age at first event (years) 13.75 13.17 14.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.16 11.26 [6.92, 18.32] 1.8e-22 91
15 years 0.09 13.68 [8.23, 22.74] 6.1e-24 49
5 years 0.02 14.76 [7.04, 30.97] 1.1e-12 10
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T1D_STRICT – Type 1 diabetes, strict definition
GWS hits:

Survival analyses between endpoints

Plot

before Type 1 diabetes, strict definition
after Type 1 diabetes, strict definition

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Drugs most likely to be purchased after Type 1 diabetes, strict definition