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Type 1 diabetes, strict (exclude DM2)

DOID EFO MESH SNOMED PheWeb

E4_DM1_STRICT

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not E4_DM2

299608

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

3972

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E4_DM1_STRICT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 3972 1978 1994
Unadjusted prevalence (%) 1.12 1.00 1.27
Mean age at first event (years) 21.03 20.19 21.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.88 [3.03, 7.87] 7.4e-11 178
15 years 0.02 3.10 [1.78, 5.39] 6.5e-5 71
5 years 0.01 6.55 [3.84, 11.18] 5.5e-12 39
1 year 0.00 18.57 [10.80, 31.93] 4.6e-26 23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1_STRICT – Type 1 diabetes, strict (exclude DM2)
GWS hits:

Survival analyses between endpoints

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Plot

before Type 1 diabetes, strict (exclude DM2)
after Type 1 diabetes, strict (exclude DM2)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes, strict (exclude DM2)

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